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In laboratory research, it is used to study receptor-mediated signaling in pituitary models and downstream IGF-1 pathway activity

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[2] Arizona has a cardiovascular disease burden that mirrors the national average: the CDC estimates that heart disease accounts for approximately 22% of all deaths in Arizona annually

In the SUSTAIN-6 trial, injectable semaglutide demonstrated a notable effect in reducing the incidence of nonfatal stroke (hazard ratio [HR] 0.61

Therefore, our study provides a new approach that is generalizable to map endogenous cell membrane interactomes for G-protein-coupled receptors to decipher the molecular basis of their cell-type-specific functional regulation